September 10, 2025Advanced ScienceOpen Access

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

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Authors

YDYongguo DaiCentral South University XGXiaoling GuoWenzhou Medical University PYPengxia YuHubei University of Medicine

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Implication

Observational analysis shows glucose intolerance rising in offspring with intrauterine growth restriction, indicating hepatic signaling changes via GR/miR‐1224 programming.

Key Points

Insulin resistance shifted to glucose intolerance by postnatal week 36 in offspring from intrauterine growth restriction.
Offspring initially showed improved glucose tolerance, but developed insulin resistance later with age.
The IUGR model was established through prenatal caffeine exposure, affecting insulin signaling pathways.
Findings highlight the role of glucocorticoid receptor and miR‐1224 in the regulation of insulin sensitivity postnatally.

Cite This Study

Dai et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787bae https://doi.org/10.1002/advs.202510277

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Implication

Observational analysis shows glucose intolerance rising in offspring with intrauterine growth restriction, indicating hepatic signaling changes via GR/miR‐1224 programming.

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

Discussion

Member takes

Implication

Key Points

Cite This Study

Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR‐1224 Programming

Discussion

Member takes

Implication

Key Points

Cite This Study

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