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September 10, 2025Cell DiscoveryOpen Access

Intrauterine hyperglycemia impairs mouse primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference

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Authors

JCJiangshan CongQLQing LiYLYangyang Li

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Overview

Experimental analysis reveals intrauterine hyperglycemia disrupts primordial germ cell development in females, suggesting sex-specific epigenetic implications.

Key Points

  • Intrauterine hyperglycemia reduces fertility by disrupting primordial germ cell (PGC) development, especially in females.
  • Male primordial germ cells show less severe changes, yet still exhibit impaired DNA methylation in key imprinted genes.
  • Hyperglycemia affects chromatin accessibility and gene expression in a sex-specific manner, highlighting the role of epigenetics.
  • These findings suggest long-term developmental impacts on future generations due to disrupted sex differentiation mechanisms.

Cite This Study

Cong et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea61894https://doi.org/10.1038/s41421-025-00821-0
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