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September 5, 2025The Journal of PhysiologyOpen Access

Metformin and insulin exacerbate one‐carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas

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Authors

DZDayna ZimmermanJBJessica F. BriffaDKDewei Kong

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Overview

Analysis reveals altered one-carbon metabolism and physiological changes in fetuses associated with growth restriction and antihyperglycaemic treatments.

Key Points

  • Disruptions to one-carbon metabolism contribute to intergenerational transmission of gestational diabetes.
  • Growth-restricted rats exhibited a lower S-adenosylmethionine:S-adenosylhomocysteine ratio, indicating reduced methylation capacity.
  • Antihyperglycaemic medications like metformin and insulin exacerbate one-carbon metabolism deficits in pregnant growth-restricted rats.
  • Fetuses from treated mothers displayed changes in pancreatic islet ratios and altered enzyme expression in the placenta.

Cite This Study

Zimmerman et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d64777c11https://doi.org/10.1113/jp289453
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