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This research aims to explore the mechanisms linking placental ischemia, mitochondrial function, and blood pressure differences between sexes.

December 19, 2025Physiological GenomicsOpen Access

Rodents Exposed to Placental Ischemia in Utero Display Sex Differences in Brain miRNA Expression, Mitochondrial Function, and Blood Pressure in Adulthood

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Rodent model reveals sex differences in mitochondrial function and blood pressure linked to oxidative stress in IUGR.

This research aims to explore the mechanisms linking placental ischemia, mitochondrial function, and blood pressure differences between sexes.
IUGR and control Sprague Dawley rats were evaluated at 16-18 weeks of age.
Animals were derived from placental ischemia dams (IUGR) and normal pregnancies (control).
Differentially expressed miRNAs were identified, focusing on let-7d-3p and its effects on mitochondrial function and blood pressure.
IUGR males showed high blood pressure and increased oxidative stress, linked to mitochondrial dysfunction.
11 differentially expressed miRNAs were identified, notably let-7d-3p, which was upregulated in IUGR males.
Control females exhibited no significant changes in ATP production despite increased GFM-1 and ETC proteins.

Smith et al. (2025) studied this question.

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