September 10, 2025Immunopathologia PersaOpen Access

Immunohistochemical biomarkers for predicting malignant transformation in oral leukoplakia and lichen planus: a systematic review study

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SASarah A. AliKing Abdulaziz University AJAhoud JazzarKing Abdulaziz University YMYasmin MairKing Abdul Aziz University Hospital

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Systematic review analyzes immunohistochemical biomarkers predicting malignant transformation in oral leukoplakia and lichen planus, suggesting clinical implications.

Key Points

Bcl-2 and p53 are significant immunohistochemical markers indicating potential malignant transformation in oral premalignant lesions.
The systematic review analyzed 10 studies with a total of 549 participants focusing on immunohistochemical biomarkers in oral leukoplakia and lichen planus.
Immunohistochemical analysis highlighted the importance of Ki-67 and Bax for understanding cell proliferation and apoptotic balance in these lesions.
A panel of biomarkers, particularly Bcl-2 and p53, shows strong potential for enhancing risk assessment and clinical management for patients with oral leukoplakia and lichen planus.

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Ali et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d64783e76 https://doi.org/10.34172/ipp.2025.43919

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Implication

Systematic review analyzes immunohistochemical biomarkers predicting malignant transformation in oral leukoplakia and lichen planus, suggesting clinical implications.

Immunohistochemical biomarkers for predicting malignant transformation in oral leukoplakia and lichen planus: a systematic review study

Discussion

Member takes

Implication

Key Points

Cite This Study

Immunohistochemical biomarkers for predicting malignant transformation in oral leukoplakia and lichen planus: a systematic review study

Discussion

Member takes

Implication

Key Points

Cite This Study

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