Systematic review and meta-analysis reports increased malignant transformation in oral leukoplakia, highlighting cancer hallmarks and oncogenic events.
Key Points
Malignant transformation in oral leukoplakia is significantly increased with hyperproliferative lesions, enhancing cancer risk.
The hallmark of sustaining proliferation was observed in 56.30% of leukoplakia cases, strongly linked to malignancy with a relative risk of 1.92.
Longitudinal cohort studies assessed molecular events in oral leukoplakia, using immunohistochemical techniques for biomarker analysis.
Findings suggest that mechanisms like epithelial–mesenchymal transition and immune evasion play crucial roles in oral cancer development.
Cite This Study
González‐Ruiz et al. (2025) studied this question.