July 23, 2025CancersOpen Access

Hallmarks of Cancer Expression in Oral Leukoplakia: A Scoping Review of Systematic Reviews and Meta-Analyses

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Scoping review synthesizes evidence on hallmarks of cancer in oral leukoplakia, indicating gaps in understanding malignant transformation mechanisms.

Oral leukoplakia is a common potentially malignant disorder with unclear molecular progression to cancer.
The review included 22 systematic reviews, highlighting activation of invasion and metastasis as a key hallmark.
Key oncogenic mechanisms in OL involve sustained proliferation and evasion of growth suppressor signals.
Findings emphasize significant evidence gaps in understanding specific hallmarks and mechanisms in OL malignant transformation.

González‐Ruiz et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark

Scoping review synthesizes evidence on hallmarks of cancer in oral leukoplakia, indicating gaps in understanding malignant transformation mechanisms.