The state of the immune system in patients with leukoplakia and squamous cell carcinoma of the oral mucosa

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Open cohort study reveals immune dysfunction in leukoplakia and oral squamous cell carcinoma, suggesting clinical implications.

Patients with leukoplakia and LSIL show immune system dysfunction, marked by decreased cytotoxic T cells and elevated IL-18 levels.
A significant drop in cytotoxic T and B lymphocytes occurs in oral squamous cell carcinoma patients with increased proinflammatory cytokines.
The study followed an open cohort design and included patients with leukoplakia, squamous cell carcinoma, and a control group of healthy individuals.
Conditional immune changes indicate the need for further research into the immune response related to oral lesions.

Карпук et al. (2025) studied this question.

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