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July 12, 2025Critical Reviews in Oncology/HematologyOpen Access

Novel insight into the Warburg effect: Sweet temptation

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Authors

HZHeng ZhangSLS Y LiuSFShengfeng Fu

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Overview

This review explores the warburg effect's role in tumor cells, revealing its metabolic adaptations and potential drug targets for cancer treatment.

Key Points

  • MAIN FINDING: The warburg effect represents a critical shift in glucose metabolism in tumor cells.
  • KEY EVIDENCE: Elevated aerobic glycolysis activity is linked to enhanced proliferation and invasion of cancer cells.
  • APPROACH: Factors like glycolytic enzymes and tumor microenvironment are examined for their roles in the warburg effect.
  • SIGNIFICANCE: Insights into the warburg effect could lead to novel therapeutic strategies and early cancer diagnosis.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cbf04https://doi.org/10.1016/j.critrevonc.2025.104844
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Warburg Effect and its Role in Tumorigenesis2025
  2. 2Targeting the glycolytic switch in cancer: mechanisms, cancer progression and therapeutic challenges2025
  3. 3Deciphering enemy tactics – the narrow path to an optimal anti-cancer strategy targeting the Warburg effect2025
  4. 4Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours2025
  5. 5Glycolytic reprogramming in cancer: tumour cell metabolism, immune modulation, and therapeutic opportunities2026