Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Chinese MedicineOpen Access

Astrocyte inhibition and PV interneuron activation: key mechanisms in electroacupuncture's effect on pain-anxiety comorbidity

View Full Paper
Ask AI
Bookmark
Share

Authors

JFJunfan FangYXYashuang XuMQMengting Qiu

Discussion

Loading...

Member takes

Overview

Research demonstrates electroacupuncture reduces pain and anxiety in CFA mice, implicating PV interneurons and astrocytes as key mediators.

Key Points

  • Electroacupuncture significantly alleviated pain and anxiety-like behaviors in CFA mice, showing its therapeutic potential.
  • Activation of PV interneurons and inhibition of astrocytes in the anterior cingulate cortex were triggered by electroacupuncture.
  • Findings indicate that chemogenetic manipulation of astrocytes reversed the analgesic effects of electroacupuncture on pain and anxiety.
  • Adenosine A1 receptors play a crucial role in mediating the interplay between astrocytes and PV interneurons in this context.

Cite This Study

Fang et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64781fb3https://doi.org/10.1186/s13020-025-01202-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Synergistic Effect of Heat Therapy and Electroacupuncture Treatment in Inflammatory Pain Mouse Models2025
  2. 2Ventral Anterior–Lateral Complex of the Thalamus Mediates Chronic Stress‐Induced Pain Hypersensitivity and Underlies Electroacupuncture Analgesia2025
  3. 3Electroacupuncture Alleviates Neuropathic Pain by Inhibiting Spinal CCL2-Driven Microglial Activation2025
  4. 4Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain2025
  5. 5Electroacupuncture Relieves Fibromyalgia Pain in a Female Mouse Model by Augmenting Cannabinoid Receptor 1 Expression and Suppressing Astrocyte and Microglial Activation in Nociceptive Pathways2025