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September 10, 2025BiomedicinesOpen Access

Electroacupuncture Relieves Fibromyalgia Pain in a Female Mouse Model by Augmenting Cannabinoid Receptor 1 Expression and Suppressing Astrocyte and Microglial Activation in Nociceptive Pathways

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Authors

IHI-Han HsiaoMLMing-Chia LinHHHsin‐Cheng Hsu

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Overview

Electroacupuncture demonstrates pain relief by enhancing CB1 expression and suppressing microglial activation in a mouse model of fibromyalgia.

Key Points

  • Electroacupuncture effectively alleviates both mechanical and thermal hyperalgesia in fibromyalgia-affected mice.
  • A notable increase in cannabinoid receptor 1 expression was observed in multiple brain regions following electroacupuncture treatment.
  • The study utilized a mouse model under intermittent cold stress to assess nociceptive responses using specific pain tests.
  • Activation of the CB1 pathway may provide a new therapeutic strategy for treating fibromyalgia pain.

Cite This Study

Hsiao et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a7bcdhttps://doi.org/10.3390/biomedicines13092112
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemogenetic Modulation of Electroacupuncture Analgesia in a Mouse Intermittent Cold Stress-Induced Fibromyalgia Model by Activating Cerebellum Cannabinoid Receptor 1 Expression and Signaling2025
  2. 2Electroacupuncture Attenuates Fibromyalgia Pain Through Increased PD-1 Expression in Female Mice2025
  3. 3The Synergistic Effect of Heat Therapy and Electroacupuncture Treatment in Inflammatory Pain Mouse Models2025 · 4 citations
  4. 4Electroacupuncture Alleviates Neuropathic Pain by Inhibiting Spinal CCL2-Driven Microglial Activation2025
  5. 5Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain2025 · 3 citations