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September 18, 2025International Journal of Molecular SciencesOpen Access

Electroacupuncture Alleviates Neuropathic Pain by Inhibiting Spinal CCL2-Driven Microglial Activation

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Authors

VSVishnumolakala SindhuriMKMoses KooSJSohee Jeon

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Overview

Experimental study shows electroacupuncture improves pain in neuropathic rats, suggesting CCL2 involvement.

Key Points

  • Electroacupuncture significantly alleviated mechanical allodynia and thermal hyperalgesia in neuropathic rats.
  • Assessment revealed lower CCL2, CCR2, Iba1, and pro-inflammatory cytokines in the electroacupuncture group.
  • Intrathecal CCL2 administration completely reversed the analgesic effects of electroacupuncture treatment.
  • Findings highlight a critical role of CCL2/CCR2 signaling in mediating the analgesic effects of electroacupuncture.

Cite This Study

Sindhuri et al. (2025) studied this question.

synapsesocial.com/papers/68d433b0713b0b5dfea733bahttps://doi.org/10.3390/ijms26189049
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Analgesic Effect of NLRP3 Inflammasome in the Relief of Inflammatory Pain by Electroacupuncture: A Systematic Review and Meta-Analysis of Animal Studies2025
  2. 2Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain2025
  3. 3The Synergistic Effect of Heat Therapy and Electroacupuncture Treatment in Inflammatory Pain Mouse Models2025
  4. 4Effect of electroacupuncture on interleukin-6 and procalcitonin expression in the astrocytes and neurons of the spinal cord dorsal horn in a rat model of incisional pain2025
  5. 5Astrocyte inhibition and PV interneuron activation: key mechanisms in electroacupuncture's effect on pain-anxiety comorbidity2025