Chronic restraint stress caused pain sensitivity in mice, revealing the ventral anterior-lateral complex's role in electroacupuncture's analgesic effects.
Key Points
Chronic stress resulted in pain hypersensitivity, including mechanical allodynia and thermal hyperalgesia.
Electroacupuncture alleviated chronic stress-induced hypersensitivity, targeting specific neuronal pathways in the thalamus.
Chemogenetic approaches demonstrated the role of VAL CaMKIIα-positive neurons in managing chronic stress-related pain.
The study highlights novel therapeutic strategies for addressing pain associated with emotional disorders.