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August 23, 2025Acupuncture in Medicine

Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain

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Authors

YYYi YingGYGuodong YangXLXiaoyu Li

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Overview

Electroacupuncture reduces neuropathic pain symptoms in a rat model, suggesting its potential as a complementary therapy.

Key Points

  • Electroacupuncture significantly improved pain-related behaviors in the chronic constriction injury rat model, contributing to analgesic effects.
  • Key evidence showed that EA reduced p38 MAPK activation and microglial response, indicating anti-inflammatory properties.
  • Inhibition of p38 MAPK with SB203580 reversed hyperalgesia, demonstrating the pathway's role in neuropathic pain management.
  • These findings support the use of electroacupuncture as a complementary therapy for managing neuropathic pain in clinical settings.

Cite This Study

Ying et al. (2025) studied this question.

synapsesocial.com/papers/68af76b97567bf4f94fefb5fhttps://doi.org/10.1177/09645284251363987
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