September 10, 2025Open Access

Figure S7 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

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Discussion

Observational analysis reveals altered metabolism in pancreatic cancer cells exposed to etomoxir, suggesting PPARδ's role in promoting metastasis.

Altered metabolic responses in pancreatic cancer cells indicate a role for PPARδ in metastasis.
After treatment with etomoxir, significant changes in PPAR expression and downstream targets were observed.
The findings highlight the influence of microenvironmental cues on cancer metabolism and progression.
Investigating PPARδ's metabolic orchestration offers potential insights into therapeutic strategies.

Parejo-Alonso et al. (2025) studied this question.

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Observational analysis reveals altered metabolism in pancreatic cancer cells exposed to etomoxir, suggesting PPARδ's role in promoting metastasis.