September 10, 2025Open Access

Figure S4 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

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Discussion

Analysis reveals that PPARδ mediates a prometastatic metabolic response in pancreatic cancer, indicating crucial roles of microenvironmental cues.

Epithelial-to-mesenchymal transition was induced, highlighting the role of metabolic response in cancer progression.
Key findings show that etomoxir and MCM treatment promote transition at the single-cell level in pancreatic cancer.
Experimental approach included single-cell analysis methods to study the effects of microenvironmental cues.
Understanding this pathway may lead to new therapeutic strategies targeting pancreatic cancer metastasis.

Parejo-Alonso et al. (2025) studied this question.

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Analysis reveals that PPARδ mediates a prometastatic metabolic response in pancreatic cancer, indicating crucial roles of microenvironmental cues.