September 10, 2025Open Access

Figure S12 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

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Authors

BPBeatriz Parejo-AlonsoInstituto de Investigación Sanitaria Aragón DBDavid BarnedaBabraham Institute STSara Maria David TrabuloAstraZeneca (United Kingdom)

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Implication

Observational analysis reveals that downregulating MYC reverses the prometastatic phenotype induced by etomoxir in pancreatic cancer, indicating potential therapeutic strategies.

Key Points

Downregulation of MYC reverses the prometastatic phenotype, enhancing treatment potential.
Experiments show that blocking PPARδ can alter metabolic responses in pancreatic cancer cells.
Analysis focuses on the influence of microenvironmental cues in cancer cell metabolism.
Findings may help identify new strategies for targeting pancreatic cancer metastasis.

Cite This Study

Parejo-Alonso et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64782039 https://doi.org/10.1158/0008-5472.30029468

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Implication

Observational analysis reveals that downregulating MYC reverses the prometastatic phenotype induced by etomoxir in pancreatic cancer, indicating potential therapeutic strategies.

Figure S12 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Discussion

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Implication

Key Points

Cite This Study

Figure S12 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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