September 10, 2025Open Access

Figure S8 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

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Discussion

Analysis finds PPAR-δ promotes lipidomic changes and epithelial-mesenchymal transition in pancreatic cancer, suggesting new therapeutic targets.

PPAR-δ activity drives significant lipidomic changes, facilitating metastatic behavior in pancreatic cancer.
Lipid profiling revealed alterations linked to epithelial-mesenchymal transition due to PPAR-δ activation.
The study highlights the role of PPAR-δ in regulating metabolic responses during cancer progression.
Targeting PPAR-δ may provide a new avenue for therapeutic intervention in pancreatic cancer.

Parejo-Alonso et al. (2025) studied this question.

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Analysis finds PPAR-δ promotes lipidomic changes and epithelial-mesenchymal transition in pancreatic cancer, suggesting new therapeutic targets.