September 10, 2025Open Access

Figure S2 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

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Discussion

Observational analysis reveals no impact on CD133 or self-renewal in PDAC cells from etomoxir treatment with macrophage-conditioned medium.

No changes in CD133 expression or self-renewal were observed in pancreatic cancer cells after treatment.
The treatment involved etomoxir and macrophage-conditioned medium, indicating potential metabolic interactions.
The metabolic response to microenvironmental cues plays a significant role in pancreatic cancer progression.
Findings suggest that PPARδ may orchestrate metabolic pathways in pancreatic cancer without altering stemness markers.

Parejo-Alonso et al. (2025) studied this question.

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Observational analysis reveals no impact on CD133 or self-renewal in PDAC cells from etomoxir treatment with macrophage-conditioned medium.