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September 5, 2025Open Access

Tables S1 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

Analysis reveals EGFR activation in NF1-mutant melanoma cultures, suggesting targeted therapy options.

Key Points

  • EGFR activation is promoted by NF1 loss, enhancing sensitivity to EGFR inhibition in melanoma.
  • Short term cultures show pronounced EGFR activity, highlighting potential therapeutic pathways.
  • Collective findings suggest the need for targeted therapy in NF1-mutant melanoma patients.
  • The research provides insight into targeted interventions for improved melanoma management.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fbb9https://doi.org/10.1158/0008-5472.30029843
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S6 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Table S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Table S7 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Figure S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Table S3 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025