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September 5, 2025Open Access

Table S2 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

Differential gene expression affects EGFR activity in NF1-mutant melanoma, suggesting treatment strategies.

Key Points

  • NF1 loss enhances EGFR activation, leading to increased sensitivity to EGFR inhibitors.
  • Gene expression analysis shows marked differences between NF1 mutant and wild type samples.
  • The findings derive from a comparative assessment of mutant and wild type NF1 melanoma models.
  • These results imply new avenues for targeted therapies in NF1-mutant melanoma patients.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fbc1https://doi.org/10.1158/0008-5472.30029867
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S7 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Table S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Figure S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Table S3 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Table S8 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025