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September 5, 2025Open Access

Table S3 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

Differential analysis reveals EGFR activation in NF1-mutant melanoma, indicating potential treatment sensitivities.

Key Points

  • EGFR activation is enhanced by NF1 loss, leading to increased sensitivity to EGFR inhibitors.
  • Analysis shows differential alterations in chromatin accessibility related to EGFR activation.
  • ATAC Seq was used to assess chromatin accessibility in NF1-mutant melanoma samples.
  • Findings highlight the role of NF1 loss in modulating response to EGFR-targeted therapies.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fba7https://doi.org/10.1158/0008-5472.30029864
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Table S7 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Table S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Table S8 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Table S10 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025