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September 5, 2025Open Access

Table S7 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

Analysis reveals increased EGFR activation in NF1 mutant melanoma, suggesting potential targeted therapies.

Key Points

  • EGFR activation is significantly higher in NF1 mutant melanoma compared to wild type.
  • This activation correlates with increased sensitivity to EGFR inhibition therapy.
  • Findings indicate a potential therapeutic strategy targeting EGFR in NF1 mutant melanoma.
  • Improvement in treatment outcomes may be observed with EGFR inhibitors in these patients.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fb80https://doi.org/10.1158/0008-5472.30029852
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Figure S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Table S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Table S6 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Figure S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025