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September 5, 2025Open Access

Figure S5 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

Observational analysis shows selective sensitivity to EGFR inhibition in NF1-mutant melanoma, indicating new treatment avenues.

Key Points

  • NF1 mutant melanoma cells exhibit selective sensitivity to EGFR inhibition.
  • Sensitivity to EGFR inhibition occurs independently of BRAF or NRAS mutation status.
  • This observational analysis highlights a potential target for therapy in NF1-mutant melanoma.
  • Further research is needed to confirm outcomes in broader clinical settings.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fbc5https://doi.org/10.1158/0008-5472.30029879
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Figure S2 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma2025
  2. 2Figure S3 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma2025
  3. 3Figure S4 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma2025
  4. 4Table S2 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma2025
  5. 5Table S7 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma2025