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September 5, 2025Open Access

Table S5 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

KEGG pathway analysis highlights EGFR activation in NF1-mutant melanoma, suggesting effective targeting with inhibition.

Key Points

  • EGFR activation leads to increased sensitivity to inhibition in NF1-mutant melanoma, enhancing treatment potential.
  • Key evidence reveals distinct gene expression patterns in NF1 mutant compared to wild type, impacting therapeutic strategies.
  • The study employs KEGG pathway analysis of differentially expressed genes to explore functional implications in melanoma.
  • These findings suggest that targeting EGFR may provide improved strategies for managing NF1-related melanoma.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fbb2https://doi.org/10.1158/0008-5472.30029858
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Table S9 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Table S12 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Table S7 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Table S3 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025