Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Open Access

Table S9 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

View Full Paper
Ask AI
Bookmark
Share

Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

Discussion

Loading...

Member takes

Overview

KEGG pathway analysis demonstrates EGFR inhibition impact in NF1-mutant melanoma, suggesting potential therapeutic strategies.

Key Points

  • NF1 loss significantly promotes EGFR activation, ultimately enhancing sensitivity to EGFR inhibition.
  • The pathway analysis of differentially expressed genes reveals critical mechanisms influenced by EGFR in NF1-mutant melanoma.
  • Observational analysis of gene expression changes focuses on NF1 and EGFR interactions in melanoma cells.
  • These findings suggest potential for targeted therapy in NF1-mutant melanoma cases.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fbc2https://doi.org/10.1158/0008-5472.30029846
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S8 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Table S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Table S10 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Table S12 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Table S3 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025