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September 5, 2025Open Access

Effect of citrulline malate supplementation during a multicomponent exercise program on physical function and biochemical parameters in physically active older women: a randomised controlled pilot trial

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Authors

RRRafael Ramos-HernándezJPJorge Pascual-FernándezÁMÁlvaro Miguel‐Ortega

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Overview

Randomised controlled trial demonstrates improved physical function and biochemical markers in older women, suggesting citrulline malate benefits health.

Key Points

  • Citrulline malate supplementation improved sit-to-stand performance and 6MWT distance in older women, indicating enhanced physical function.
  • Participants receiving citrulline malate showed significant improvements in SPPB score and serum vitamin D levels, compared to the placebo group.
  • The randomized controlled trial included 33 community-dwelling women aged 65+, highlighting the potential for citrulline malate in preserving physical function.
  • Results suggest citrulline malate could prevent functional decline in aging women, though further research is needed for confirmation.

Cite This Study

Ramos-Hernández et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e835https://doi.org/10.21203/rs.3.rs-7337173/v1
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Also Consider

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  3. 3Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes2025
  4. 4Effects of Multicomponent Training on Metabolic and Functional Health of Older Women With Obesity: A Randomized Clinical Trial2025
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