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September 5, 2025Asian Journal of Health Research

L-Citrulline Supplementation in Postmenopausal Women: Evidence from Clinical Trials

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Authors

SPSatya Alfarisma PanggabeanIMIntan Syarifatin MumtazahLALaily Nur Rachmah Wati Putri Arifianti

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Overview

Systematic review reveals L-Citrulline significantly improves cardiovascular outcomes and muscle function in postmenopausal women, suggesting a potential non-pharmacological intervention.

Key Points

  • L-Citrulline supplementation significantly reduces systolic and diastolic blood pressure in postmenopausal women.
  • Improvements in flow-mediated dilation (FMD) were noted, enhancing endothelial function and nitric oxide availability.
  • Supplementation led to increased muscle oxygenation and strength, especially when combined with resistance training.
  • L-Citrulline also improved heart rate variability, indicating a favorable modulation of autonomic regulation.

Cite This Study

Panggabean et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c260https://doi.org/10.55561/ajhr.v4i2.256
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1L-citrulline as a nitric oxide–modulating therapeutic adjunct to exercise: effects on vascular function, arterial stiffness, and cardiometabolic health in postmenopausal and older women2026
  2. 2Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes2025 · 5 citations
  3. 3Effect of citrulline malate supplementation during a multicomponent exercise program on physical function and biochemical parameters in physically active older women: a randomised controlled pilot trial2025 · 1 citations
  4. 4Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes2025 · 2 citations
  5. 5Short-term administration of L-citrulline augments cardiac vagal control and reduces blood pressure in response to high-intensity exercise in untreated hypertensive males2026