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September 5, 2025NutrientsOpen Access

Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes

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Authors

AFArturo FigueroaKDKatherine N. DillonDLDanielle E. Levitt

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Overview

Randomized crossover trial shows citrulline boosts microvascular function and muscle strength in T2D patients, indicating potential therapeutic benefits.

Key Points

  • Citrulline supplementation significantly improved microvascular endothelial function and muscle strength in T2D patients.
  • Participants receiving citrulline had an increase in endothelial function measurements, reaching statistical significance in multiple outcomes.
  • The trial involved sixteen middle-aged and older adults with T2D, comparing effects of citrulline versus placebo over a crossover period.
  • The findings support using citrulline to address vascular and muscle-related complications of aging in T2D patients.

Cite This Study

Figueroa et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a16chttps://doi.org/10.3390/nu17172790
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