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September 5, 2025Journal of Experimental & Clinical Cancer ResearchOpen Access

ECM-Induced IL-23 Drives Immune Suppression in Breast Cancer via Regulating PD-1 on Tregs

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Authors

GTGiovanna TalaricoMLMara LecchiAZAnna Zanichelli

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Overview

Observational analysis uncovers IL-23's impact on PD-1 expression in Tregs of breast cancer patients, indicating potential therapeutic targets.

Key Points

  • Enhanced IL-23 levels in ECM3⁺ tumors correlated with lower PD-1 expression on regulatory T cells.
  • Mouse models showed that SPARC promotes IL-23 release, inducing SATB1, which represses the pdcd1 gene.
  • Blocking IL-23 restored PD-1 in Tregs and activated T effector cells, highlighting new treatment strategies.
  • ECM3 status may serve as a biomarker for resistance to PD-1/PD-L1 blockade, suggesting alternative therapies.

Cite This Study

Talarico et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c415https://doi.org/10.1186/s13046-025-03518-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer2025
  2. 2Tumor extracellular matrix enhances invasive gene expression of breast cancer cells in 3D patient-derived scaffolds2025
  3. 3In-depth proteomic profiling of the extracellular matrix of pancreatic ductal adenocarcinomas identifies signatures correlating with lymphocyte infiltration2025
  4. 4Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets2025
  5. 5Extracellular Matrix-Guided Tumor Stratification and Network Models Reveal Clinical Molecular Grades2025