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September 10, 2025Open Access

Extracellular Matrix-Guided Tumor Stratification and Network Models Reveal Clinical Molecular Grades

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ADAslı DansıkSSSevgi SarıcaEÖEce Öztürk

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Overview

Analysis reveals ECM-based tumor grades in lung cancer patients, suggesting distinct therapeutic strategies.

Key Points

  • Higher ECM grades correlate with distinct clinical features and tumor dynamics, enhancing prognostic value.
  • Multi-omic data identified patient groups with varying ECM grades, linking them to mutation profiles.
  • Network modeling revealed pathways enriched in higher ECM grades related to epithelial-mesenchymal transition and cancer stemness.
  • Drug proximity analysis indicated olaparib as ECM-grade dependent, supporting targeted therapeutic interventions.

Cite This Study

Dansık et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d647832fahttps://doi.org/10.1101/2025.08.29.672994
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