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September 10, 2025Scientific ReportsOpen Access

Tumor extracellular matrix enhances invasive gene expression of breast cancer cells in 3D patient-derived scaffolds

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Authors

PPParmida Sadat PezeshkiNGNegar Mohammadi GanjaroudiAAAshkan Azimzadeh

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Overview

Observational analysis revealed enhanced invasive gene expression in breast cancer cells on tumor extracellular matrix, implying significant implications for targeting ECM.

Key Points

  • Cells cultured on tumor patient-derived scaffolds exhibited significant overexpression of invasive genes.
  • Collagen and glycosaminoglycans were significantly overexpressed in tumor scaffolds compared to normal ones.
  • The study utilized a 3D culture model of breast cancer cells to assess gene expression patterns.
  • Targeting the mechanobiological properties of tumor ECM may provide therapeutic avenues for aggressive breast cancer.

Cite This Study

Pezeshki et al. (2025) studied this question.

synapsesocial.com/papers/68c23e94b210217d64792acahttps://doi.org/10.1038/s41598-025-12196-z
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