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September 5, 2025Discover OncologyOpen Access

LncRNA ADAMTS9-AS1 regulates the proliferation, migration, and invasion of esophageal cancer cells via miR-575/ CADM2

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Authors

JWJinhua WangWJWei JiHQHongxia Qu

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Overview

This study demonstrates the role of lncrna ADAMTS9-AS1 in regulating miR-575 and CADM2 in esophageal cancer, suggesting its potential as a prognostic biomarker.

Key Points

  • Overexpression of lncrna ADAMTS9-AS1 significantly inhibits the proliferation, migration, and invasion of esophageal cancer cells.
  • ADAMTS9-AS1 expression negatively correlates with miR-575 levels, while positively correlating with CADM2 in esophageal cancer tissues.
  • Cox model analysis indicates that ADAMTS9-AS1 is a risk factor for poor prognosis in esophageal squamous cell carcinoma.
  • Manipulating ADAMTS9-AS1 expression affects the miR-575/CADM2 axis, altering the function and progression of esophageal cancer.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477be00https://doi.org/10.1007/s12672-025-03248-x
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