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August 8, 2025Frontiers in OncologyOpen Access

CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway

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Authors

LHLiubing HouZHZerui HaoGZGe Zhang

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Overview

Observational analysis shows CD9 enhances proliferation and radioresistance in esophageal squamous cell carcinoma, suggesting a new therapeutic target.

Key Points

  • CD9 overexpression increases migration and radioresistance in esophageal squamous cell carcinoma, indicating its role in tumor aggressiveness.
  • High CD9 levels correlate with poorer clinical outcomes, particularly in patients undergoing radiotherapy, suggesting prognostic implications.
  • Assessment using TCGA data and functional assays revealed CD9 activates the AKT/GSK3β signaling pathway, critical for ESCC growth.
  • Findings highlight the potential of CD9 as a target for improving treatment responses in esophageal squamous cell carcinoma patients.

Cite This Study

Hou et al. (2025) studied this question.

synapsesocial.com/papers/68af2b68cf1dd9ea359e4cbehttps://doi.org/10.3389/fonc.2025.1625120
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