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September 5, 2025International Journal of Molecular SciencesOpen Access

Amino Acid Profile Alterations in the Mother–Fetus System in Gestational Diabetes Mellitus and Macrosomia

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Authors

NFNatalia FrankevichATAlisa TokarevaSYS. Yu. Yuriev

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Overview

Analysis finds specific amino acid markers in the mother-fetus system, indicating GDM and macrosomia risk.

Key Points

  • Significant alterations in the amino acid profile were found in the mother-fetus system related to GDM and macrosomia.
  • Maternal serum increased 5-OH-lysine and homocitrulline in GDM, while cord blood showed higher isoleucine and serine.
  • Machine learning techniques and metabolic pathway analysis were utilized to identify 19 altered amino acids across samples.
  • Glutamine, histidine, and asparagine could serve as early biomarkers for predicting macrosomia in gestational diabetes.

Cite This Study

Frankevich et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477b191https://doi.org/10.3390/ijms26178351
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Features of the Metabolomic Profile in Gestational Diabetes Mellitus2025
  2. 2Gestational diabetes mellitus: the role of IGF-1 and leptin in cord blood2025
  3. 3Early metabolic biomarkers in neonates of diabetic mothers: predictive insights from amino acid and acylcarnitine profiling2025
  4. 4Metabolomic Signatures of Transitional Breast Milk in Gestational Diabetes Mellitus: A Case–Control Study Assessing the Impact of Insulin Therapy2025
  5. 5Serum D-Dimer, Glycated Serum Protein, and HbA1c Levels in Predicting Macrosomia in Gestational Diabetes Mellitus.2025