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August 19, 2025Journal of Perinatal MedicineOpen Access

Gestational diabetes mellitus: the role of IGF-1 and leptin in cord blood

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Authors

AKAlexandra KrauseKSKarl Otfried SchwabJTJeffrey G. Trost

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Overview

Observational study shows elevated IGF-1 and leptin in large for gestational age infants, suggesting metabolic dysregulation in gestational diabetes.

Key Points

  • Elevated IGF-1 and leptin levels are significantly associated with fetal macrosomia and large for gestational age newborns.
  • The study involved 127 mother-infant dyads over a 5-month period, with significant differences noted in biochemical markers.
  • Measurement of IGF-1, leptin, insulin, and other markers in cord blood used ELISA in comparison with control infants.
  • Findings imply metabolic differences between gestational diabetes and control infants may remain undetected under tight diabetes control.

Cite This Study

Krause et al. (2025) studied this question.

synapsesocial.com/papers/68af33e3cf1dd9ea359e8ffbhttps://doi.org/10.1515/jpm-2024-0379
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal Gut Microbiota in Gestational Diabetes Mellitus and Fetal Macrosomia: Is There an Association?2025
  2. 2Fetal Outcome in Patients with Gestational Diabetes Mellitus2025
  3. 3Amino Acid Profile Alterations in the Mother–Fetus System in Gestational Diabetes Mellitus and Macrosomia2025
  4. 4Prenatal Ultrasonographic Markers of Macrossomia and C-Peptide in Gestational Diabetes Mellitus: A Prospective Cohort Study2025
  5. 5Association of Circulating miRNAs from the C19MC Cluster and IGF System with Macrosomia in Women with Gestational Diabetes Mellitus2025