Through Network Pharmacology Combined with Artificial Intelligence Techniques, Potential Targets of Banxia Xiexin Decoction for the Treatment of Functional Dyspepsia were Identified and Validated

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Network pharmacology reveals BXD targets in functional dyspepsia, highlighting immune activation involvement.

BXD demonstrated significant inhibition of p-STAT3 levels in vivo, indicating its therapeutic effects in FD.
The study identified seven hub genes through PPI analysis, with p-STAT3 emerging as a primary target for BXD's effects.
Machine learning techniques, including XGBoost, were essential for predicting key targets and assessing their importance.
In vivo experiments confirmed that BXD improved gastrointestinal motility and mitigated mucosal barrier damage.

Ren et al. (2025) studied this question.

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Network pharmacology reveals BXD targets in functional dyspepsia, highlighting immune activation involvement.

BXD demonstrated significant inhibition of p-STAT3 levels in vivo, indicating its therapeutic effects in FD.
The study identified seven hub genes through PPI analysis, with p-STAT3 emerging as a primary target for BXD's effects.
Machine learning techniques, including XGBoost, were essential for predicting key targets and assessing their importance.
In vivo experiments confirmed that BXD improved gastrointestinal motility and mitigated mucosal barrier damage.

Ren et al. (2025) studied this question.

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