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October 12, 2025Frontiers in EndocrinologyOpen Access

Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis

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Authors

LPLee Yam PoonLHLi-Feng HsuLLLai Kwan Lam

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Overview

Network pharmacology and molecular docking reveal key components, suggesting β-sitosterol may inhibit DR biomarkers.

Key Points

  • Modified Danggui Buxue Decoction effectively reduces biomarkers associated with diabetic retinopathy.
  • Core components like beta-sitosterol and significant differentially expressed core genes were identified.
  • Machine learning and MR analysis linked elevated ERBB2 levels to increased diabetic retinopathy risk.
  • In vitro studies demonstrated that beta-sitosterol inhibits specific proteins and inflammatory markers in DR.

Cite This Study

Poon et al. (2025) studied this question.

synapsesocial.com/papers/68ebc91af2c3e4d8d926e301https://doi.org/10.3389/fendo.2025.1648831
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