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December 4, 2025Biomedical Chromatography

Banxia Xiexin Decoction Ameliorates Ulcerative Colitis via a Flora‐Metabolite‐Inflammation Axis Through Integrated Metabolomic and Microbiome Analysis

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Authors

WSWentao ShaoLLLong LiYTYi Tao

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Overview

Integrated metabolomic analysis reveals BXD reduces colonic inflammation in ulcerative colitis, highlighting its role in regulating pro-inflammatory cytokines and microbiota.

Key Points

  • BXD significantly mitigates colonic inflammation in ulcerative colitis, enhancing gut health.
  • Treatment led to a reduction of pro-inflammatory cytokines IL-1β and IL-6, improving intestinal barrier integrity.
  • Metabolomic and microbiome analysis demonstrated BXD's modulation of tryptophan metabolites and regulation of gut microbiota.
  • Findings support BXD's therapeutic potential through its multi-target actions against inflammation.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/6930dc6bea1aef094cca2054https://doi.org/10.1002/bmc.70275
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Also Consider

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  5. 5Yuyang Decoction Regulates Macrophage Polarization and Repairs the Intestinal Mucosal Barrier via the TLRs/Tollip Signaling Pathway2025