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September 16, 2025MedicineOpen Access

Exploring the mechanism of Zhengan Xifeng decoction in treating Parkinson disease based on network pharmacology and molecular docking

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Authors

YXYidan XuGYGuangjun Yu

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Overview

This research demonstrates that Zhengan Xifeng decoction effectively targets multiple pathways in Parkinson disease, suggesting its potential for comprehensive treatment.

Key Points

  • Zhengan Xifeng decoction showed new potentials for treating Parkinson disease, revealing 139 active ingredients and 119 related targets.
  • The three top active ingredients identified were β-sitosterol, palmitic acid, and calcium carbonate, with strong binding affinities to key proteins.
  • Using network pharmacology and molecular docking, the study identified important pathways, notably the neuroactive ligand-receptor interaction pathway.
  • The findings provide a theoretical foundation for future experimental validation and the development of anti-Parkinsonian products.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d4232f713b0b5dfea6b417https://doi.org/10.1097/md.0000000000044587
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