September 5, 2025Neuropsychology

Explicit and implicit representation of reward value in cocaine use disorder (CUD): A mouse kinematic study on intertemporal decision-making.

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Discussion

Kinematic analysis reveals decision-making patterns in cocaine use disorder, suggesting tailored therapeutic interventions.

CUD patients showed higher discount rates compared to healthy controls, indicating altered decision-making.
Mouse kinematics allowed differentiation between immediate and future choices in CUD patients with distinct trajectories.
Significant correlations were found between kinematic measures and psychiatric indices, revealing underlying cognitive dynamics.
Results highlight the potential for using kinematic data to inform neurobiological classification of addictive disorders.

Calluso et al. (2025) studied this question.

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