August 7, 2025Open Access

Cocaine use disorder is associated with lower brain state transition energy particularly in higher order and excitatory networks

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Authors

HBHussain Bukhari ABAliza Brzezinski-RittnerDouglas Mental Health University Institute SSS. Parker SingletonChildren's Hospital of Philadelphia

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Implication

Observational analysis reveals lower transition energy in brain networks of individuals with cocaine use disorder, suggesting altered dynamics of neurotransmitter systems.

Key Points

People with cocaine use disorder exhibit significantly lower global transition energy in brain networks, which impacts their behavior.
Lower transition energy was particularly evident in the default mode and dorsal attention networks, highlighting specific neural disruptions.
Analysis utilized network control theory to assess brain dynamics across individuals with cocaine use disorder vs. controls.
Findings indicate that prolonged cocaine use may lead to diminished brain energy, linking excitatory neurotransmitter dysfunction to impaired inhibitory control.

Cite This Study

Bukhari et al. (2025) studied this question.

synapsesocial.com/papers/68af2979cf1dd9ea359e337f https://doi.org/10.1101/2025.08.06.668699

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Implication

Observational analysis reveals lower transition energy in brain networks of individuals with cocaine use disorder, suggesting altered dynamics of neurotransmitter systems.

Cocaine use disorder is associated with lower brain state transition energy particularly in higher order and excitatory networks

Discussion

Member takes

Implication

Key Points

Cite This Study

Cocaine use disorder is associated with lower brain state transition energy particularly in higher order and excitatory networks

Discussion

Member takes

Implication

Key Points

Cite This Study

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