July 29, 2025Open Access

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

View Full Paper

Ask AI

Bookmark

Authors

MLMontana Kay LaraUniversity of Vermont LCLieselot L. G. CarretteUniversity of California, San Diego TSThiago Missfeldt SanchesUniversity of California, San Diego

Discussion

Member takes

Implication

Genome-wide association study reveals significant genetic associations linked to cocaine self-administration in Heterogeneous Stock rats, suggesting new therapeutic targets.

Key Points

The study identifies six genome-wide significant associations related to cocaine use disorder (CUD).
One significant locus on chromosome 19 is linked to carboxylesterase genes, important for cocaine metabolism.
Findings suggest several candidate genes related to addiction behaviors, including Trak2 related to CUD in humans.
This research offers new insights for developing pharmacological strategies against cocaine use disorder.

Cite This Study

Lara et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cebbd https://doi.org/10.1101/2025.07.17.660811

View Full Paper

Ask AI

Bookmark

Implication

Genome-wide association study reveals significant genetic associations linked to cocaine self-administration in Heterogeneous Stock rats, suggesting new therapeutic targets.

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider