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September 5, 2025Open Access

Context-specific impact of antimicrobial stewardship on antibiotic use and antibiotic resistance in hospitals in a lower-middle income country - results from an implementation study with a controlled interrupted time series design in Vietnam

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Authors

TLTrang TL LeDVDung Tien Viet VuQLQuang Minh Le

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Overview

Implementation study evaluates antimicrobial stewardship effects on antibiotic use and resistance, suggesting variability in outcomes between hospitals.

Key Points

  • The AMS intervention reduced antibiotic use in Hospital 1, while Hospital 2 showed no change in antibiotic use.
  • Hospital 1 displayed a decrease in antibiotic resistance for E. coli, but resistance increased for P. aeruginosa.
  • While the intervention affected antibiotic use, it did not lead to any significant changes in mortality rates.
  • The study highlights the importance of tailoring AMS interventions based on local resistance patterns and implementation challenges.

Cite This Study

Le et al. (2025) studied this question.

synapsesocial.com/papers/68c23887b210217d6477805fhttps://doi.org/10.1101/2025.08.25.25334341
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effectiveness of a Hospital-Based Antimicrobial Stewardship Program: A Three-Year Observational Study2025
  2. 2Multidisciplinary administrative-professional-technical interventions to optimize antibiotic use and reduce resistance in a tertiary general hospital2025
  3. 3Multidrug-resistant organism carriage in Vietnamese district hospitals before and after an antimicrobial stewardship intervention2026
  4. 4Impact evaluation of an antimicrobial stewardship team intervention based on AWaRe guidelines: a single- center, cohort, interrupted-time series study2025
  5. 5Interrupted time-series analysis to evaluate the impact of a national antimicrobial stewardship campaign on antibiotic use among primary healthcare institutions: evidence from Central China2025