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August 16, 2025Open Access

Epigenetic markers of middle-age: non-linear DNA methylation changes with aging in humans

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Authors

ASAkiyoshi ShimuraKYKyosuke YamanishiTITakaya Ishii

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Overview

Analysis reveals non-linear age-related dna methylation changes in individuals, indicating complex aging processes.

Key Points

  • Non-linear DNA methylation patterns were observed with peaks in middle age, not a simple trajectory.
  • Among 864,627 CpG sites analyzed, 8.4% increased and 23.9% decreased in methylation with age.
  • Hierarchical multiple regression detected both linear and non-linear associations in a large-scale analysis.
  • Findings suggest programmed processes may influence gene expression at specific ages, affecting disease onset.

Cite This Study

Shimura et al. (2025) studied this question.

synapsesocial.com/papers/68af70687567bf4f94feba39https://doi.org/10.1101/2025.08.14.670237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-specific non-linear DNA methylation trajectories across aging predict cancer risk and systemic inflammation2025
  2. 2Epigenetic signature of heterogeneity in aging: Findings from the Canadian Longitudinal Study on Aging2025
  3. 3DNA methylation landscapes in human cells and their chromatin determinants2025
  4. 4DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 12 citations
  5. 5DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 3 citations