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September 5, 2025Open Access

Epigenetic signature of heterogeneity in aging: Findings from the Canadian Longitudinal Study on Aging

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Authors

OVOlga VishnyakovaJMJoosung MinXSXiaowei Song

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Overview

Research reveals how methylation variability affects aging patterns in diverse health outcomes.

Key Points

  • The study identified 448 differentially methylated regions associated with health decline across health deficits.
  • It found 488 differentially variable regions, highlighting the role of methylation variability in aging processes.
  • Observational analysis used blood samples from 1,445 Canadians aged 45 to 85 to investigate aging heterogeneity.
  • The epigenetic biomarker constructed showed improved prediction of mortality and chronic obstructive pulmonary disease.

Cite This Study

Vishnyakova et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a5f2https://doi.org/10.1101/2025.08.25.671156
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