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September 18, 2025Frontiers in ImmunologyOpen Access

TGM2 regulated by transcription factor NR3C1 drives p38 MAPK-mediated tumor progression and immune evasion in lung squamous cell carcinoma

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Authors

CLChunlong LinSLShangfu LiYLYi Liang

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Overview

Analysis reveals TGM2's role in tumor progression and immune evasion in lung squamous cell carcinoma, regulated by NR3C1.

Key Points

  • High TGM2 expression in lung squamous cell carcinoma correlates with reduced overall survival and disease-free survival.
  • TGM2 activation of p38 MAPK signaling promotes tumor proliferation, migration, and invasion in lung cancer cells.
  • Elevated TGM2 levels lead to an immunosuppressive microenvironment, with decreased Th1 and NK cell infiltration.
  • NR3C1 regulates TGM2 expression, indicating its potential as a therapeutic target in lung squamous cell carcinoma.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68d435cf713b0b5dfea74efehttps://doi.org/10.3389/fimmu.2025.1595907
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