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August 21, 2025Frontiers in ImmunologyOpen Access

Comprehensive analysis based on the ubiquitination- and deubiquitylation-related genes reveals the function of NEURL3 in esophageal squamous cell carcinoma

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Authors

YLYi‐Wei LinHLH LiCHChao‐Qun Hong

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Overview

Comprehensive examination identifies a prognostic signature for esophageal squamous cell carcinoma, suggesting immune response and drug sensitivity implications.

Key Points

  • The prognostic signature comprised 11 genes and accurately predicted the prognosis of esophageal squamous cell carcinoma patients.
  • Two molecular subtypes of ESCC were identified, with C2 subtype showing significantly shorter overall survival compared to C1 subtype.
  • Assessment revealed that the risk score correlates with immune cell infiltration and markers, enhancing understanding of immune response.
  • Loss-of-function studies indicated that NEURL3 may inhibit proliferation and motility in ESCC cell lines.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68af70627567bf4f94feb856https://doi.org/10.3389/fimmu.2025.1632090
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