Analysis finds DTL overexpression correlates with tumor progression in esophageal squamous cell carcinoma, suggesting potential as a prognostic biomarker.
Key Points
Overexpression of DTL mRNA was found in all tested ESCC cell lines, indicating its role in tumor proliferation.
Multivariate analysis showed that DTL positivity is a significant poor prognostic factor in ESCC, with a hazard ratio of 2.4.
Knockdown of DTL expression significantly impaired cell proliferation and induced G2/M arrest, highlighting its importance in cancer progression.
Immunohistochemical analysis revealed DTL overexpression in 25% of ESCC tumors, linking it to advanced tumor stages.