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August 26, 2025MedScienOpen Access

Research Progress on Lactate-Mediated Tumor Metabolic Microenvironment-Driven Immunotherapy and Metabolic Reprogramming Strategies

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QSQianhui Sun

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Overview

Systematic review reveals lactate modulates immune cell function in tumors, suggesting metabolic therapy implications.

Key Points

  • Lactate inhibits T cell glycolytic activity and promotes regulatory T cell differentiation in tumors, complicating immunotherapy.
  • Results highlight that lactate levels influence T cell dynamics and response to treatments like PD-1 antibodies.
  • Comprehensive analysis across TCGA/GEO databases illuminates the link between metabolic enzyme expression and patient prognosis.
  • Future strategies should incorporate dynamic lactate monitoring and nano-drug delivery for better clinical outcomes.

Cite This Study

Qianhui Sun (2025) studied this question.

synapsesocial.com/papers/68af7df27567bf4f94ff4f70https://doi.org/10.61173/xtckva87
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Lactate Metabolism in Tumors2025 · 6 citations
  2. 2Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies2025 · 32 citations
  3. 3Metabolic–immune nexus in tumor microenvironment: From mechanistic insights to therapeutic opportunities2025 · 11 citations
  4. 4Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation2025
  5. 5Glycolytic reprogramming in cancer: tumour cell metabolism, immune modulation, and therapeutic opportunities2026